So I had this idea when thinking about and discussing Sam (that being Samuel's wolf) and how much better behaved he is than say, Bran's wolf.
We talk a lot about dominance when it comes to wolves, but obviously, there are a lot more dimensions than that. In this case, I had the idea to plot dominance as a "y-axis" as it seems natural to visualize dominance on a vertical scale. On the "x-axis" we then have a measure of how crazy the wolf is when in control.

Most wolves, Mercy says, are more-or-less dominant. So most wolves who survive the Change are in the upper right hand quadrant, with alphas and Charles and Sam at the top and Bran as the upper right hand corner (At least for American wolves).
Submissive wolves exist in the lower right hand corner (Although perhaps they actually belong in the lower left, now that I think about it. I would have to see some with the wolf in control to know).
Omegas take up the upper left. Note: I don't know exactly where to put Rick and Anna. I don't think there are enough omegas out there to really decipher the spectrum of "omega-ness," and being omega makes it hard also to assess dominance. But to the left of the line is the "zen zone," either way, and if they were below the x-axis in submissive territory I don't think they would be inclined to refuse orders from the other wolves.
My theory is that the anyone whose wolf would be in the fourth quadrant, would not survive the Change.
If we look at this on an algebraic scale, the +,+ wolves have a need to protect any wolf who falls into a quadrant that has at least one negative.
If I could, I would plot another dimension, related to the human's control... all wolves with a negative "z-axis" value have to be killed for the safety of others, but in the positives you seemingly have a pretty good range.